I am not aware of any research, I've only connected the dots from my experience. I was super pale growing up, had orthostatic hypotension, dry skin, sweated insanely during puberty, and felt like I got progressively stupider as I got into my early 20s. I developed hypertension, and I drank lots of diet energy drinks from 16-20 and felt better when I did.

At some point, I got genetic testing done through 23andme, ran that info through software that revealed health info, and it showed I had a genoset that heavily affects phenylalanine processing. I started taking a stimulant and tyrosine, and I've felt better ever since.

My genetic oddity also affects NO synthesis, and will probably lead to my death through heart attack or stroke. It's gs224 if you're interested in the specifics.