In my experience, there are actually networks that throttle certain kinds of traffic. For example, on the WiFi on Blauwnet trains I can connect to my OpenVPN server but WireGuard just doesn't seem to make it through. I assume this is because of a combination of unknown ports + UDP + uncommon protocols.
I think the trick to bypass this kind of nonsense is to use port 443/1194/53 so QoS + firewall rules will still allow the VPN to pass through.
Haven't tested it yet, but in my experience non-default ports only make the problem worse. Most filtering/QoS services are pretty dumb and will just match source and destination ports; most firewalls will just plain ignore everything targeted at port 443 because the moment you start messing with HTTPS, you're in for a world of pain. Because WireGuard uses UDP, it's possible to listen on port 443 even if you're already hosting an HTTPS website. Sadly, you won't be able to use QUIC or HTTP3 if you do, but I don't think that's much of an issue these days.