Comparisons are stupid but still:
Compare loopholes with game glitches. They are not intended, they break the system and every player is hated for using them.
Often "pro-loopholers" claim that everyone tries to optimize their tax, so why not big companies. But tax breaks which are used by the regular guy have clear implications: Support families, incentivize businesses, steer society in a certain direction. Loopholes are just edge cases that have not been thought of, thus have to be closed as soon as possible. They are the glitch in a perfect tax law. Don't exploit them!