I've been using Prisma in for some months now (even in production), and I'm a big fan of the product. With TypeScript you have an easy full autocompletion & type checking over your models, and coupled with a graphql-yoga server & graphqlgen for the exposed GraphQL part it has been a pretty nice experience.

The downside is (because there is always some), as it's a new tech, problems can pop up and more research have to be made compared to a more old and popular framework.

In any case, I highly recommend you to try it on your own, I'm looking foward to its futur improvements.