The Integral Fast Reactor was a reality in 1994, including a reprocessing scheme and inherent safety, when congress cut its funding. It's not my favorite reactor. My favorite, the molten chloride fast reactor, was theoretically investigated in 1972, including its potential for transmutation of actinides (excellent), I-129, Tc-99 (both good) and even Sr-90 and Cs-137 (both rather pointless).
What could go wrong and in fact did go wrong is politics. That's what prevents the practical investigations.