"ultimately, when heat waves are extreme enough, power plants will need to draw down their power output."[1]
Here [2] is a study which shows anthropogenic heat emissions from energy consumption are a pressure on global climate. If we put out another 200%+ of whatever energy we consume, in the form of thermoelectric cooling (heat) then quite surely that will amount to a bigger problem.
Also, "Thermoelectric power use has a significant impact on water resources and the power sector is highly dependent on these water resources; the United States Geological Survey (USGS) estimated on a national level that 41% OF ALL FRESHWATER WITHDRAWALS in the United States in 2005 were for thermoelectric power operations, primarily for cooling needs (Kenny et al 2009)."[3]
I believe the real game changers are plainly solar and wind. These have shown the most rapid improvements from investment. On similar timescale to developing fission or secure nuclear, floating oceanic wind and solar combined with hydrogen generation rigs (and even ocean plastic filtering) are possible...
[1] https://www.sciencedirect.com/topics/earth-and-planetary-sci...
[2] https://link.springer.com/article/10.1007/s10584-017-2092-z
[3] https://iopscience.iop.org/article/10.1088/1748-9326/7/4/045...