The subject of the article was shot with a 22WMR (Winchester Magnum Rimfire) round. This round can use the same bullet as the 22lr round but contains lots more powder.
The velocity of the bullet leaving the barrel of the firearm depends on how fast the charge contained in the casing wants to push it and how much the barrel wants to slow it down due to friction. Almost all rifles barrels are between 16.5" and 24". For a average 22WMR round shooting an 40-grain (unit of mass) bullet out of a mid-length rifle barrel one would expect the bullet to leave the barrel at around 2000 feet/sec. The deceleration caused by friction can be altered by changing the exterior-most material of the bullet: a full metal jacket (usually lead totally encased by copper) is potentially slicker than a jacketed soft-point (only partially encased, with the tip exposed).
A Ruger Single Six is a type of handgun. The story describes a single-action revolver, which the Single Six is not, but let's ignore that. It comes in barrel lengths of 2.75", 4", and 6". Out of a 4" or 6" barrel, the 22WMR has about 1400-1600 feet/sec of velocity. This is roughly comparable with the upper (or hot) range for a 22lr fired out of a rifle barrel.