Life depends on dimensions up to some point too. The most typical example is that, in a 2D world, there cannot be organisms that consume food, because the digestive tube would split the organism in two.
We also have amoeba which ingest food through vacuoles. But yes, a through-gut would be impractical.
By what reasoning would it not be a single membrane in two dimensions, but it would be in three dimensions? As far as I can tell your only support/reasoning is found when you write "IMHO"...
In 2 dimensions, the membrane is essentially a line (or a linear sequence of objects) - if that line is interrupted in one space to let stuff through, then it's not connected anymore, it's two separate lines with nothing linking them, it's broken with no possibility to connect "around the hole" because any connection around the hole requires the third dimension, and any connection through the hole closes that hole.