I want the majority of the road network roofed with turf into a long hill with occaisional exits, or lowered and moved completely underground.
At least that's what I've worked out from Cities: Skylines.
Skyways are significantly cheaper than bridges. It would still be cheaper to make the ground level of your city a building, but not having to support the mass of cars and trucks means skyways can be significantly cheaper.
In the modern world trucks and buses are far too useful to ban completely from cities where people live. People need their stuff delivered, and need to get longer distances once in a while. Thus I'm saying reserve the ground for those uses and get humans away from them. It is a compromise, but I think it is a good one.