I think even one on one, a sufficiently large constrictor could take down (asphyxiate, if not eat) a full sized floridian. But that's not accounting for tool use, which changes the matter completely.
If you've never seen a large constrictor grab prey it's easy to dismiss them as slow and easily avoidable. But these strike with incredible speed, and can wrap themselves completely around their prey in a second or two. Then the squeezing starts... A knife or a gun is only helpful if you can reach it and use it quickly enough.
But, when not hungry, especially if digesting a large meal, they tend to hide, don't really move and are pretty much harmless.
So it really depends if the snake is in hunting mode or not.