So yeah, if an F-15 blindly stumbles within the effective range of an S400 it will be shot down.
The fingerprint of the S400's radar are detectable from thousands of kilometers away and a nice little icon will be plopped onto the pre-mission overlays before the F-15 takes off.
You don't even have to detect the radar beam, you can detect the data link.
As for casualties, what casualties?
The only casualties a drone launching a glide bomb results in are those on the receiving end.