Near the end when the hosts were wrestling about whether they should think he was guilty, the interviewer's friend (the producer? Dana?) came on and shared why she thought he was guilty, and it was this convoluted argument about if Syed was innocent, he'd have to be the unluckiest guy in the world, so therefore he was probably guilty.
Her point was that it was just too strong a coincidence that it was his ex-girlfriend that got killed, on that particular day during some period of time when he didn't have an alibi, etc etc.
That seemed to me like it could be a bad Bayesian argument - like it would have been a good argument had Serial selected a random citizen to interview, but they selected someone they already knew was connected to the story. Murders happen and by definition the circumstances are always highly unlikely because murders are so rare, and innocent people closely connected to the circumstances of the crime are very, very unlucky by definition. You can't point to that unluckiness as evidence that they're probably guilty.