It seems to me that the Interstate Commerce Clause has pretty much sidestepped a large portion of the rest of the Constitution of the US.
That is quite literally within the original Constitutional scope of the interstate commerce clause. No amendment needed...
Prohibition required an amendment because at the time most alcohol was brewed/distilled/whatever locally and sold locally, so the amount of interstate alcohol commerce was limited and would not have survived constitutional review. (Now, most alcohol is made in a few states and sold nationally, so the interstate commerce clause would apply as a matter of original scope.)