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Carrier pigeons, but not at any weight worth the trouble.

Is it an African or European pigeon?

Better to use a European pigeon, less likely to get pulled over.

Depends on the drug. Maybe not cocaine, but LSD is typically potent enough to be profitably haulable by avian logistics systems.

It's synthetic, so there's little reason to transport it cross border or long distance.

What's the difference between synthetic and manufactured?

I think the difference is between the one which you can grow Vs the one which you can synthesize.

If you can grow a drug then you need to move it if you can synthesize it locally then there is no need to transport it.

Synthesizing a drug has much smaller footprint so easier to hide the operation Vs growing some drug.

I'd say that manufactured covers all processes, so extracted from a plant is manufactured but not synthetic.