Windows Defender is on every machine, so what would be the point of writing a virus that is detected by it? The same for Kaspersky. These programs are easy to test against and well-known. They are designed to work against old viruses that have already been detected and analyzed.

It's better to use lesser known antivirus products with good heuristic detection. I will not mention names but there are a number of products out there, including ones that block every executable not on a whitelist.