I always find any work from home I do to be uncomfortable - my home isn't set up for work, and my house is full of distractions. And the boundaries disappear between the "home" and "work" - I can't just ignore emails if they pop up even if I'm done working, as there doesn't seem to be a discrete line anymore, I'm on call 24/7. I'm always worried about not answering the email, as I'm worried the boss will go "why isn't he working at 4 pm?".