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In my mind that’s what makes this kind of a garbage study.

Alongside focus on just osteoporosis, lack of control for calcium levels (other than blind supplementing with low dietary intake), phosphate levels.

Some people may be responding poorly to the supplement, especially at high doses and low calcium. Direct blood test for status would help.

CAC tests are a good indication if D3+K2+mag is mobilizing calcium. That is of course if your current CAC score is above 0 which it should not be.

I wonder if taking mega-doses of vitamin D without K2 would drain the subject's stored supply of K2, leaving none for other processes in which K2 plays a role (?)

Also... Magnesium!

And... Strontium!

This.