Einstein's theory hasn't yet been reconciled with quantum theory. That's a good place to watch for progress.
Though we'd have to hope that, unlike that novel, we don't accidentally set off a vacuum collapse. That would be unfortunate.
We just need to observe the collisions happening at these energies - we don't necessarily need to produce them ourselves.
Some physicists are starting to think about how we might be able to observe naturally occurring collisions at these energy levels rather than producing them ourselves.
I'm having trouble finding the articles I've read on the subject - I'll follow back up if I do manage to find 'em.
[0]: http://backreaction.blogspot.com/2019/03/nonsense-arguments-...