I don't do drugs recklessly. I don't have reckless sex. I do not think these things should be okay to do until and unless you take the proper care to do them without causing harm to others. If you don't take the proper care, then it doesn't matter whether the danger you run afoul of is "natural" or "artificial". Taking the proper care obviates both types of dangers.
Don't be reckless, or the life you ruin might not be your own.