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To anyone curious, this was studied at a small scale with promising results across several psychedelics. Most notably lsd and mdma (in addition to mushrooms and dmt). I can't seem to locate links to studies at the moment, but I'd suggest reading How to change your mind by Michael Pollan if you're interested in this stuff.

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I went to a talk last week by Robin carhart-harris who does deep research in this area. The talk itself was pretty complicated but he was saying (I think!) that they believe these drugs cause the brain to go into a state where it becomes more susceptible to change. The same thing happens under extreme stress / trauma. The context of the experience itself then determines how that’s encoded. It’s like it opens the brain up to change.

Yes. I've done a lot of reading on the subject trying to explain and begin to understand how the incredibly positive changes I've experienced come about...and "reverse PTSD" seems remarkably close. A guided, safe psychedelic session is similar in that it's a one-time, extremely powerful event that causes a lasting change in the brain--except in this case it's positive and intentional* whereas PTSD is negative and wasn't sought out.

* There seems to be a large degree of choice in which changes one wants to take away from the experience but this is a highly subjective, personal conclusion.

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