The layout engine in flash was REALLY well thought out, and allowed for simple constraints that would allow for things to grow or shrink based on screen size. You could anchor buttons and they would move properly, all without having to worry about things breaking across browsers.
If someone would re-implement just this feature along from flash i would be REALLY excited to use it!
So far i dont think there is really much in the way of "constraint based" layout engines that are easy to use for the web is there?