Calvin and Hobbes was syndicated. What do you mean?
I may be off on this a little, as I did a little reading to verify. Waterson was opposed to having other people write and draw the Calvin & Hobbs cartoon for him. He noted that so many other cartoons had done this and their quality had plumetted.
From memory (because it was written in his last book, and I can't find it online) he said that when he couldn't make a new cartoon every day and be happy with the quality, he would be done.
Edit: I may be conflating syndication with licensing.... :P