Will look into it. I have experience with python, matlab/octave, R, and an itsy bitsy amount of C#/SQL/Java from another life (figuratively).
http://mathema.tician.de/software/pycuda
even Matlab has some bindings for CUDA:
http://developer.nvidia.com/object/matlab_cuda.html
Bare in mind however that the original CUDA implementation uses C, so if you want the last drop of performance you will use C.