Generally speaking, yes, they do. But the answer is, as always, more complex than that. Firstly, some types of games (text adventures, MUDs etc.) are more favorable for enjoynment by visually impaired people. When it comes to the traditional genres, it usually ends up being an issue, e. g. the mainstream games more often than not are not playable, but there's an entire genre of games which do not rely on visual information and instead use audio (usually stereo + might be some HRTF tricks).

I'm blind and play games. I have some residual vision to navigate some GUIs and use OCR to read blocks of text and magnification for a few other things, like detecting small buttons. I tend to pick a game and learn it well and play it a lot. I'm working my way through Disco Elesium right now, it's amazing.