1. Meetups geared towards a demographic I'm not part of (the biggest occurrence is 50+ meetups)
2. Meetups that are a shill for some MLM, other scheming
3. Tech meetups on subjects that dont particularly interest me
4. Bar / bar hopping meetups, but everyone is decades older than me
I do agree about the general uselessness of Meetup.com though.
I do ask questions and discuss with people, but I don't get any closer then this, which results in an even worse feel of loneliness in the end.
Assuming you like the activity (please allow yourself at least three months of constant practice before drawing conclusions) you will almost automatically pick up social contacts through that.
Just join any Sportverein! If you don't like exercise, then Chess or something. There are thousands of Sportvereine (and other types of Vereine) in each city, pick one (or three), go regularly.