This can get super heated. There was a controversial "glitchless" run of Mirror's Edge at GDQ a few years back...
Sometimes people make a "no major glitches" or "no OOB" category, where specific glitches are disallowed, but others are allowed.
Sometimes people make a "no major glitches" or "no OOB" category, where specific glitches are disallowed, but others are allowed.