If you're talking about a daily dose, it is really something a doctor should be aware of and give a stamp of approval. It's a blood thinner, which means if you have any other anticoagulant med or issues it can be dangerous.
Relatively speaking, it also has a fair low LD50. For a person around 150lb, 40 standard 325mg pills can be fatal. In fact you'll almost never, outside of hospital supply, find the 81mg chewable version in quantities higher than 36 in case children get a hold and think they're candy. Even then, a 2 year old downing a whole bottle would still be close to an LD50.
All in all, despite being extremely common and cheap to the point of nearly free ($10 for a year's daily supply) it is actually less safe than other NSAID class drugs. But then none of this stuff, strictly speaking, is "safe" if it is used outside of it's normal use parameters.