In my experience, each sufficiently complicated model becomes non-linear in some respect. For example, you might want to work with margins for time-slots that are non-linear but smooth.

So, even though I've worked with constrained linear programming in the past, I tend to prefer algorithms with meta-heuristics, such as simulated annealing or Tabu search. Although this might not provide the 'best' solution, it provides a wider range of modelling tools.

To elaborate a bit on a use-case. Lets say we want to plan a high-school roster. Teachers might have a maximum of 8 hours per day of work, but if we make a hard cut-off at that time, we might miss an interesting 8:15 schedule that gives a teacher more time to have proper lunch. If, furthermore, we do not break the 40 hr./week rule, it might be a workable schedule. Also, it provides the search algorithm a usable gradient, so the search space becomes smooth and easier to navigate. Finally, if we provide several top solutions, we give a human planner information on how the problem is (over-)constrained.