I found this old presentation making a set of hypothesis regarding Alz etiology, possible mechanisms and possible treatments somewhat interesting: https://www.youtube.com/watch?v=j1FmK4582mA.

I am obviously biased towards this concept, as I have personally seen my mom slow reverse her early dementia with the help of an experimental Mercury removing drug, but since Alzheimer is really only confirmed by Autopsy, and we happen to live close by a Chlor Alkali plant that has been dumping Hg to the environment for decades, we would never know if she would have eventually died / get diagnosed of Alz.