no.

Apple will just slowly write itself into the equation so that little snitch can no longer mess with whatever muddled idea apple seems to think is important.

Already with Catalina you have to connect to apple and ask permission before you can even install little snitch. That means little snitch can't protect you from apple, even if you've told apple "my machine doesn't connect to the internet".

And your machine contacts apple every bit as often as microsoft machines even though their philosophy is supposed to be different.

bottom line: you should not have to ask apple permission to do anything with your machine.