No traffic and direct paths?
Legality: how high above your property do you own? Would a drone flying at 50 feet be trespassing? 100? 200?
Loss: how do you recover a crashed drone? Or one intentionally downed?
Range: how much power can you pack onboard without compromising payload capacity?
Payload capacity: how much can you reasonably lift?
Cost: dollar for dollar, is it more cost effective than trucks (even robotic ones)?
And so on.
Drones are loud. Incredibly loud.