Open offices and the extreme micromanagement known as "agile".
Both are so toxic to mental health that I had to move away.
I haven't really left the industry itself but I've moved away from a pure engineering role (which is my true passion) to a more specialized role which is ok but not as enjoyable. But, I don't have to deal with open offices nor agile, so it's a win.
The other aspect that makes me sad is that what we call tech companies today, aren't. Their product isn't tech. Netflix is an entertainment company. Google and FB are advertising companies. And so on. Very few actual tech companies in SV today.