I think TypeScript is about as standard for Javascript as it's going to get, I feel. I can't imagine writing Javascript without it anymore. But then again it took TypeScript coming along that made writing JavaScript something tolerable outside of having to use it for work.

I don't think there's going to be any new typing system that's 5% better that everyone is going to shift to just because it's the new hotness anymore. Or at least I hope not. TypeScript is good enough, let's just stick with it for the foreseeable future if you want to write type-safe Javascript, please.

I'm still using Angular at work, and I rather like it. If I needed to make an SPA outside of work I'd probably use it over React at this point. But that's a web framework, and those seem to come and go with the wind.