I wonder there is way to put some numbers behind it. Typically, this is where natural experiments are valuable, where somewhere legalizes something and another places don't. Then you compare. But it's hard enough to imagine any jurisdiction legalizing crack or heroin, let alone doing so AND systematically capture data to answer these questions.
Since basic common sense policy that should lead to a safer and freer world is being pragmatically limited by this profit-driven system perhaps it would pay to examine that other problem as well.
Alcohol on the other hand is an actual toxin that kills cells.
The difference is that individuals taking morphine or heroine can function well with little adverse side effect. You shouldn’t drive or operate heavy machinery, but the damaging effect that alcohol has on your body is substantially worse than any morphine derivative you could possibly take.
Portugal decriminalised personal use of all drugs some time ago and it’s generally been regarded as pretty successful. [1]
The mortality rate from drugs in Portugal is 3 people per million. [2]
In the US this same measure is 217 per million. [3]
In two US states it is in excess of 400 deaths per million. [4]
[1] https://www.theguardian.com/news/2017/dec/05/portugals-radic...
[2] https://www.independent.co.uk/news/world/europe/portugal-dec...
[3] https://www.bbc.co.uk/news/uk-scotland-48938509
[4] https://www.cdc.gov/nchs/pressroom/sosmap/drug_poisoning_mor...