I want to highlight that it's not as clear-cut as this: "If you are what Paul Graham calls as relentless resourceful, you will build a successful business."
I know there are people reading who consider themselves relentless and resourceful, yet are not successful after perhaps a decade or more of trying. The mental health impact of long-term failure can be crushing (I've been there).
They should understand that there is an element of luck involved, and if they didn't make it to $20MM straight from college, that doesn't mean they're worthless or can't make it anymore. The experiences of dead-ends and failures can be channeled into something that will set them apart, but it takes honesty. Luck is not a one-way thing: you need to be in a position to take advantage of the luck that comes your way, and mentally ready to jump on it.