I've got an ErgoDox at home and a Kinesis Advantage II at work. I find the ErgoDox to be more sensible for light gaming (compared to the Kinesis), but the thumb cluster on the Kinesis is way easier (for me) to reach and navigate.

I've mostly adapted to the ErgoDox thumb cluster at this point, but prefer to do longer bouts of typing or coding on the Kinesis. The ErgoDex is more versatile but less comfortable.