We recently evaluated using Graviton2 over X86 for our Node.js app on AWS. There was enough friction, some native packages that didn't work out of the box, etc. and some key third party dependencies missing completely, that it wasn't worth the effort in the end even considering the savings, as we'd likely keep having these issues pop up and having to debug them remotely on Graviton.

If macOS goes ARM and there's a sizable population of developers testing and fixing these issues constantly, the math changes in favor of Graviton and it would make it a no-brainer to pick the cheaper alternative once everything "just works".