Everyone has different needs, but having owned pretty much every type of RV available, I'd say a truck with a fifth-wheel is much easier to mange than a coach with a flat-tow car.
A fifth-wheel is easy to backup when needed. A coach with a flat-tow car attached can't back up at all.
And as long as you have enough truck for the size fifth-wheel you have they tow much better in wind and handle curvy roads well.