I'm aware it's contextual and there are different strategies for winning, and there's a reason for each card being in the game. But I wasn't aware of how some cards combo together, or some situations/battles where they might be stronger than others, etc.

And there are plenty of discussions online for pretty much every card on how strong or weak people think the cards are overall (like is it worth picking it up if it's offered to you late in a run because the payoff might not be worth it, or if you see you're getting a specific boss that act, etc), and most of the cards have been buffed or nerfed multiple times since the game has come out, so clearly the developers have been convinced that some strong may end up stronger than others on average too (and are trying to keep things pretty even as much as possible, I assume).