Same here, I've got this one-liner in my system config:

Inverse or reverse mouse wheel (natural scrolling), reboot or unplug the mouse. Must be run in an admin powershell console.

Get-ItemProperty HKLM:\SYSTEM\CurrentControlSet\Enum\HID\\\Device` Parameters FlipFlopWheel -EA 0 | ForEach-Object { Set-ItemProperty $_.PSPath FlipFlopWheel 1 }