Great essay. I would say the game has certainly changed quite a bit with regards to remote work. I still don't feel the same energy working remote as I do in a room filled with people passionate about solving an exciting problem (i.e. a traditional startup). I think remote favors building "bazaar-type" software but not "cathedral-type" software or technology.
We're currently in a big state of flux. The character of many cities is shifting. Many folks are betting that NYC will not recover from this remote-working trend and economic downturn, for example. Are the skeptics right, or is this a short-term bump in the road?
Millions are moving from certain states and cities right now. How will this migration shape the character of destination cities like Denver? I'd say that's the more important question to speculate on rather than look back at what Denver has been in the past. I do think when you move to a place, it shapes you and you in turn shape it. It's a give and a take.