I don't have enough working knowledge or mathematics to fully comprehend the 3d pipeline but as I understand, it is a huge linear algebra/matrix manipulator and audio processing would fall into this. My reason for asking is that at least in the guitar world I've seen issues related to CPU processing and multiple VST plugins all wired together. Some guitarists use fairly complicated rigs to get their tone and when you have multiple amps, speaker cabinet simulation, and effects running you need a pretty powerful machine to do everything real-time without under-running buffers.
There are specific hardware solutions for this but I've always wondered if you could just create shaders or something and dump the audio stream to the GPU and get back the transformed audio stream with minimal CPU burden. Any insight here would be very helpful to me.