In 2020 you need HiDPI support, Wayland, and accessibility. You probably also want a toolkit that has a strong developer community. GTK and Qt have these. FLTK is under active development but it is missing a lot modern features. Maybe it will get there by 2022.
The other option, rolling your own, is a ton of work and a quite a bit of "reinventing the wheel". It's certainly possible but it needs a passionate and dedicated team.