I remember learning that “nothing” was slang for a woman’s downstairs privates, which made Much Ado About Nothing seem like a really clever title.
This exercise was more to do with the actual ordinary "plain" word meanings. In 1605, "nice" had the primary sense of "precise" or "careful and tidy", and if you don't know that this sentence, for example, doesn't parse:
Old fashions please me best; I am not so nice / To change true rules for odd inventions.