The nice thing about ketamine is that it is a sedative. I've done LSD, Mushrooms, and DMT. Ketamine is the most enjoyable and least risky in my opinion, due to its sedative nature. The doctors usually give an anti-anxiety drug before starting the infusion, a benzodiazepine such as midazolam. As I did more infusions, we increased the ketamine dose and decreased the midazolam. Find a good doctor and work with them. Ketamine is a really wonderful substance for pain and depression.