Check out SolidRun's Honeycomb LX2K. All very normal: Mini ITX, PCIe x8, DDR4 SODIMMs, USB 3.0, M.2 for NVMe. Bonus: 4 10GbE SFP+ ports.

Mine is a delight.

https://www.solid-run.com/nxp-lx2160a-family/honeycomb-works...