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Your first sentence is quite tricky to parse due to the triple negative. I parsed it as:

Most people that email you will care if you ignore them.

Is that a... triple negative?

I think you mean senders expect a response?

Let’s play a game, here’s how I would rephrase your first sentence:

You are often not the kind of person who can afford ignoring emails.

Do you triage your spam?

What is the false positive ratio, do you think?

My false positive ratio for "spam" marked automatically by gmail is around 50%. It's only that low because I started receiving occasional spam emails; it was more like 90%.

(To be clear, I've interpreted your question as "of emails that got sent to the spam folder, how many of them had no business being in there?")