It can be a drag when a bunch of correspondences come in at the same time, but I try to gently discourage people from sending me useless junk, so I'm mostly free of sifting through useless junk. Gmail/Google Apps is good enough about spam, and you can use a second email address if you need one to sign up for things like frequent flyer accounts that send spammy-ish reports.
Seriously, if you don't like your inbox, try registering a new Gmail or Google Apps account and give it out selectively to people who don't send stupid stuff, and use your old email for stuff that's overwhelming. This holds up pretty well even into the 20-40 replies per day required range, which is more than most people are going to get. The key is making sure junk doesn't get mixed in with your real email - when pretty much everything is something you'd enjoy or want to see, the inbox is not this evil cursed thing.