My first thought was "can you boot from a PCIe SSD?" (looks like the answer is "no" from what I see). I wish there was a RPi with 16GB or 32GB of storage soldered to the board. Where I work we're using Raspberry Pi devices for industrial use and corruption of/wearing out the microSD card has been something we've wondered about. We could just buy premium microSD cards but having a "proper" SSD soldered to the board would be very helpful as well.