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Comment by casefields | Hacker News Reader

Were you in poor shape in your twenties or are you also taking HGH/test through your doc? The amount of testosterone your body produces at 20 vs 64 is massive.

Testosterone and no exercise produces more lean muscle, than exercising without it. Yes, it makes that big of a difference: https://www.nejm.org/doi/full/10.1056/NEJM199607043350101

Thanks for sharing.

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Testosterone and no exercise produces more lean muscle, than exercising without it.

Please will you quote the section backing that claim, I've just spent a few minutes looking at it and can't find it - just the expected stuff about testosterone increasing muscle generally.

Edit: the mean cross-sectional bit muscle size? Basically, they make some muscles bigger but not stronger? It sounds like bloat, a mostly cosmetic thing (which has its uses) tbh.

The summary results could be clearer in their highlights perhaps; you would think your observation would be a headline and its not mentioned, though perhaps I've missed it.

They misinterpreted the study. The study is giving subjects 6x the normal replacement dose of testosterone. Way above normal levels.

The title of the study is “supraphysiologic” doses of testosterone. That means more than any man will produce naturally, at any age.

From a quick google it appears to be 6x the replacement dose.

A simple take assumes that a lower number is bad. But the research on this is far from clear. Lower testosterone may be cardioprotective.

So there are clinics everywhere for "testosterone therapy." Is this safe for an older male? What are the long-term effects? I assume it's expensive, like most cosmetic/vanity medicine. How is it different from "roids" that powerlifters and other pro athletes are known to use? Or is it different?

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